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dc.contributor.authorLi, Shan
dc.contributor.authorLi, Junhui
dc.contributor.authorZhi, Zijian
dc.contributor.authorWei, Chaoyang
dc.contributor.authorWang, Wenjun
dc.contributor.authorDing, Tian
dc.contributor.authorYe, Xingqian
dc.contributor.authorHu, Yaqin
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorChen, Shiguo
dc.identifier.citationMacromolecular properties and hypolipidemic effects of four sulfated polysaccharides from sea cucumbers, S. Li, J. Li, Z. Zhi, C. Wei, W. Wang, T. Ding, X. Ye, Y. Hu, R. J. Linhardt, S. Chen, Carbohydrate Polymers, 173, 330–337, 2017.
dc.descriptionCarbohydrate Polymers, 173, 330–337
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThe present study investigates the relationship between the high-order structure and hypolipidemic activity of four well-defined sulfated fucans from sea cucumber. The chain conformation, determined by a combination of AFM and SEC-MALLS-RI, indicate that fucosylated chondroitin sulfate (fCS) from Pearsonothuria graeffei (fCS-Pg) and Isostichopus badionotus (fCS-Ib), and fucoidan from P.graeffei (fuc-Pg) were assigned as a random coil conformation with polysaccharide chain outstretched, while I. badionotus (fuc-Ib) was assigned as a spherical conformation and exhibited high viscosity. Fuc-Pg and fuc-Ib with higher molecular weights had a greater impact in inhibiting pancreatic lipase activity in vitro. However, fCS-Pg, fCS-Ib and fuc-Pg with random linear conformation exhibited excellent hypolipidemic activity in Sprague-Dawley rats (SD rats) fed on high-fat diet (HFD), whereas fuc-Ib showed only a modest effect. Our results indicate that structural characteristics, including side branch and sulfation pattern can affect the chain conformation of polysaccharides, which determine their physicochemical properties and hypolipidemic activity.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Polymers
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleMacromolecular properties and hypolipidemic effects of four sulfated polysaccharides from sea cucumbers
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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