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Selective, switchable fluorescent probe for heparin based on aggregation-induced emission

dc.contributor.authorWang, Yi Jia
dc.contributor.authorLin, Lei
dc.contributor.authorZhang, Xing
dc.contributor.authorSchultz, Victor
dc.contributor.authorZhang, Fuming
dc.contributor.authorSun, Jing Zhi
dc.contributor.authorLinhardt, Robert J.
dc.date2016
dc.date.accessioned2022-06-27T16:02:11Z
dc.date.available2022-06-27T16:02:11Z
dc.date.issued2016-12-01
dc.identifier.citationSelective, switchable fluorescent probe for heparin based on aggregation-induced emission, Y.-J. Wang, L. Lin, X. Zhang, V. Schultz, F. Zhang, J.- Z. Sun, R. J. Linhardt, Analytical Biochemistry, 514, 48-54, 2016.
dc.identifier.issn10960309
dc.identifier.issn32697
dc.identifier.urihttps://doi.org/10.1016/j.ab.2016.09.007
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5649
dc.descriptionAnalytical Biochemistry, 514, 48-54
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractA positively charged tetraphenylethene (TPE) derivative, TPE-4MN, was synthesized as a probe for heparin based on aggregation induced emission. On the addition of 5.0 μg/mL of heparin, TPE-4MN showed an enhanced emission of about 10-fold. The change in fluorescence at 475 nm was linear over a range of heparin concentrations of 0–1.0 μg/mL with an R = 0.99988 and the limit of detection (LOD) was calculated to be 0.75 μg/mL. The mechanism of the detection was proven to be through an ion pairing interaction. TPE-4MN showed good selectivity for heparin over other types of polysaccharides and could easily distinguish heparin from heparan sulfate, a glycosaminoglycan having a similar structure to that of heparin.
dc.description.sponsorshipNational Institutes of Health
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ab.2016.09.007
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofAnalytical Biochemistry
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSelective, switchable fluorescent probe for heparin based on aggregation-induced emission
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.ab.2016.09.007
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.ab.2016.09.007
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages48-54
rpi.description.volume514


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