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dc.contributor.authorSt Ange, Kalib
dc.contributor.authorOnishi, Akihiro
dc.contributor.authorFu, Li
dc.contributor.authorSun, Xiaojun
dc.contributor.authorLin, Lei
dc.contributor.authorMori, Daisuke
dc.contributor.authorZhang, Fuming
dc.contributor.authorDordick, Jonathan S.
dc.contributor.authorFareed, Jawed
dc.contributor.authorHoppensteadt, Debra
dc.contributor.authorJeske, Walter
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationAnalysis of heparins derived from bovine tissues and comparison to porcine intestinal heparins, K. St.Ange, A. Onishi, L. Fu, X. Sun, L. Lin, D. Mori, F. Zhang, J. S. Dordick, J. Fareed, D. Hoppensteadt, Walter Jeske, R. J. Linhardt, Clinical and Applied Thrombosis and Hemostasis, 22, 520-527, 2016.
dc.descriptionClinical and Applied Thrombosis and Hemostasis, 22, 520-527
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin is a widely used clinical anticoagulant. It is also a linear glycosaminoglycan with an average mass between 10 and 20 kDa and is primarily made up of trisulfated disaccharides comprised of 1,4-linked iduronic acid and glucosamine residues containing some glucuronic acid residues. Heparin is biosynthesized in the Golgi of mast cells commonly found in the liver, intestines, and lungs. Pharmaceutical heparin currently used in the United States is primarily extracted from porcine intestines. Other sources of heparin including bovine intestine and bovine lung are being examined as potential substitutes for porcine intestinal heparin. These additional sources are intended to serve to diversify the heparin supply, making this lifesaving drug more secure. The current study examines bovine heparins prepared from both intestines and lung and compares these to porcine intestinal heparin. The structural properties of these heparins are examined using nuclear magnetic resonance, gel permeation chromatography, and disaccharide analysis of heparinase-catalyzed depolymerized heparin. The in vitro functional activities of these heparins have also been determined. The goal of this study is to establish the structural and functional similarities and potential differences between bovine and porcine heparins. Porcine and bovine heparins have structural and compositional similarities and differences.
dc.description.sponsorshipNational Science Foundation
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofClinical and Applied Thrombosis/Hemostasis
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleAnalysis of heparins derived from bovine tissues and comparison to porcine intestinal heparins
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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