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dc.contributor.authorCress, Brady F.
dc.contributor.authorTrantas, Emmanouil A.
dc.contributor.authorVerveridis, Filippos
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorKoffas, Mattheos A.G.
dc.identifier.citationSensitive Cells: Enabling Tools for Static and Dynamic Control of Microbial Metabolic Pathways, B. F. Cress, E. A. Trantas, F. Ververidis, R. J. Linhardt, M. Koffas, Current Opinion in Biotechnology, 36, 205-214, 2015.
dc.descriptionCurrent Opinion in Biotechnology, 36, 205-214
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractNatural metabolic pathways are dynamically regulated at the transcriptional, translational, and protein levels. Despite this, traditional pathway engineering has relied on static control strategies to engender changes in metabolism, most likely due to ease of implementation and perceived predictability of design outcome. Increasingly in recent years, however, metabolic engineers have drawn inspiration from natural systems and have begun to harness dynamically controlled regulatory machinery to improve design of engineered microorganisms for production of specialty and commodity chemicals. Here, we review recent enabling technologies for engineering static control over pathway expression levels, and we discuss state-of-the-art dynamic control strategies that have yielded improved outcomes in the field of microbial metabolic engineering. Furthermore, we emphasize design of a novel class of genetically encoded controllers that will facilitate automatic, transient tuning of synthetic and endogenous pathways.
dc.description.sponsorshipNational Science Foundation
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCurrent Opinion in Biotechnology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSensitive Cells: Enabling Tools for Static and Dynamic Control of Microbial Metabolic Pathways
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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