Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Recent advances in sulfotransferase enzyme activity assays, P. Paul, J. Liu, J. S. Dordick, R. J. Linhardt, Analytical and Bioanalytical Chemistry, 403, 1491–1500, 2012.
Sulfotransferases are enzymes that catalyze the transfer of sulfo groups from a donor, for example 3′-phosphoadenosine 5′-phosphosulfate, to an acceptor, for example the amino or hydroxyl groups of a small molecule, xenobiotic, carbohydrate, or peptide. These enzymes are important targets in the design of novel therapeutics for treatment of a variety of diseases. This review examines assays used for this important class of enzyme, paying particular attention to sulfotransferases acting on carbohydrates and peptides and the major challenges associated with their analysis.;
Analytical and Bioanalytical Chemistry, 403, 1491–1500; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Analytical and Bioanalytical Chemistry; https://harc.rpi.edu/;