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dc.contributor.authorMiao, Jianjun
dc.contributor.authorPangule, Ravindra C.
dc.contributor.authorPaskaleva, Elena E.
dc.contributor.authorHwang, Elizabeth E.
dc.contributor.authorKane, Ravi S.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorDordick, Jonathan S.
dc.date2011
dc.date.accessioned2022-06-27T16:08:47Z
dc.date.available2022-06-27T16:08:47Z
dc.date.issued2011-12-01
dc.identifier.citationLysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications, J. Miao, R. C. Pangule, E. E. Paskaleva, E. Hwang, R. S. Kane, R. J. Linhardt, J. S. Dordick, Biomaterials, 32, 9557-9567, 2011.
dc.identifier.issn18785905
dc.identifier.issn1429612
dc.identifier.urihttps://doi.org/10.1016/j.biomaterials.2011.08.080
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5721
dc.descriptionBiomaterials, 32, 9557-9567
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractWith the emergence of "super bacteria" that are resistant to antibiotics, e.g., methicillin-resistant Staphylococcus aureus, novel antimicrobial therapies are needed to prevent associated hospitalizations and deaths. Bacteriophages and bacteria use cell lytic enzymes to kill host or competing bacteria, respectively, in natural environments. Taking inspiration from nature, we have employed a cell lytic enzyme, lysostaphin (Lst), with specific bactericidal activity against S. aureus, to generate anti-infective bandages. Lst was immobilized onto biocompatible fibers generated by electrospinning homogeneous solutions of cellulose, cellulose-chitosan, and cellulose-poly(methylmethacrylate) (PMMA) from 1-ethyl-3-methylimidazolium acetate ([EMIM][OAc]), room temperature ionic liquid. Electron microscopic analysis shows that these fibers have submicron-scale diameter. The fibers were chemically treated to generate aldehyde groups for the covalent immobilization of Lst. The resulting Lst-functionalized cellulose fibers were processed to obtain bandage preparations that showed activity against S. aureus in an in vitro skin model with low toxicity toward keratinocytes, suggesting good biocompatibility for these materials as antimicrobial matrices in wound healing applications.
dc.description.sponsorshipNational Science Foundation
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.biomaterials.2011.08.080
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofBiomaterials
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleLysostaphin-functionalized cellulose fibers with antistaphylococcal activity for wound healing applications
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.biomaterials.2011.08.080
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.biomaterials.2011.08.080
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages9557-9567
rpi.description.volume32


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