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dc.contributor.authorKemp, Melissa M.
dc.contributor.authorKumar, Ashavani
dc.contributor.authorMousa, Shaymaa
dc.contributor.authorDyskin, Evgeny
dc.contributor.authorYalcin, Murat
dc.contributor.authorAjayan, Pulickel
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorMousa, Shaker A.
dc.date2009
dc.date.accessioned2022-06-27T16:10:54Z
dc.date.available2022-06-27T16:10:54Z
dc.date.issued2009-11-09
dc.identifier.citationGold and silver nanoparticles conjugated with heparin-derivative possess anti-angiogenesis properties, M. M. Kemp, A. Kumar, S. Mousa, E. Dyskin, M. Yalcin, P. Ajayan, R. J. Linhardt, S.A. Mousa, Nanotechnology, 20, 455104, 2009.
dc.identifier.issn13616528
dc.identifier.issn9574484
dc.identifier.urihttps://doi.org/10.1088/0957-4484/20/45/455104
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5746
dc.descriptionNanotechnology, 20, 455104
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractSilver and gold nanoparticles display unique physical and biological properties that have been extensively studied for biological and medical applications. Typically, gold and silver nanoparticles are prepared by chemical reductants that utilize excess toxic reactants, which need to be removed for biological purposes. We utilized a clean method involving a single synthetic step to prepare metal nanoparticles for evaluating potential effects on angiogenesis modulation. These nanoparticles were prepared by reducing silver nitrate and gold chloride with diaminopyridinyl (DAP)-derivatized heparin (HP) polysaccharides. Both gold and silver nanoparticles reduced with DAPHP exhibited effective inhibition of basic fibroblast growth factor (FGF-2)-induced angiogenesis, with an enhanced anti-angiogenesis efficacy with the conjugation to DAPHP (P<0.01) as compared to glucose conjugation. These results suggest that DAPHP-reduced silver nanoparticles and gold nanoparticles have potential in pathological angiogenesis accelerated disorders such as cancer and inflammatory diseases.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1088/0957-4484/20/45/455104
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofNanotechnology
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleGold and silver nanoparticles conjugated with heparin-derivative possess anti-angiogenesis properties
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1088/0957-4484/20/45/455104
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dcterms.isVersionOfhttps://doi.org/10.1088/0957-4484/20/45/455104
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.volume20


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