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dc.contributor.authorXie, Jin
dc.contributor.authorMurugesan, Saravanababu
dc.contributor.authorLinhardt, Robert J.
dc.date2008
dc.date.accessioned2022-06-27T16:11:45Z
dc.date.available2022-06-27T16:11:45Z
dc.date.issued2008-12-01
dc.identifier.citationPhysiological, Pathophysiological and Therapeutic Roles of Heparin/Heparan Sulfate, J. Xie, S. Murugesan, R. J. Linhardt, in Carbohydrate Chemistry, Biology and Medical Applications. Garg, H.G., Cowman, M.K., Hales, C.A., eds., , Chapter 10, 227-251, Elsevier, Oxford , UK, 2008.
dc.identifier.urihttps://doi.org/10.1016/B978-0-08-054816-6.00010-0
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5759
dc.descriptionin Carbohydrate Chemistry, Biology and Medical Applications. Garg, H.G., Cowman, M.K., Hales, C.A., eds., , Chapter 10, 227-251, Elsevier, Oxford, UK
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin and heparan sulfate belong to the glycosaminoglycan (GAG) family of carbohydrates. They are linear acidic complex polysaccharides found on the cell surface and in the extracellular matrix. Heparin and heparan sulfate GAGs are biosynthesized as proteoglycans (PGs) with multiple GAG chains linked to a variety of core proteins. Heparin PGs are found exclusively in the granules of subsets of mast cells, whereas heparan sulfate PGs have a much greater distribution in the body, being associated with stromal matrices, basement membranes, and almost all cell surfaces. Heparin and heparan sulfate PGs interact with cell surface binding proteins and are internalized by receptor-mediated endocytosis through their GAG chains. Heparin and heparan sulfate are the most intensively studied GAGs as a result of their anticoagulant properties. However, it has become obvious that heparin and heparan sulfate not only have anticoagulant activities but also exhibit a number of diverse biological functions including ones regulating cell growth and differentiation, inflammatory processes, host defense and viral infection mechanisms, cell–cell and cell–matrix interactions, lipid transport, and clearance/metabolism. These functions result from the direct interactions between heparin and heparan sulfate and heparin-binding proteins.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/B978-0-08-054816-6.00010-0
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Chemistry, Biology and Medical Applications
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titlePhysiological, Pathophysiological and Therapeutic Roles of Heparin/Heparan Sulfate
dc.typeBook chapter
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dcterms.isVersionOfhttps://doi.org/10.1016/B978-0-08-054816-6.00010-0
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dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages227-251


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