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dc.contributor.authorWeïwer, M.
dc.contributor.authorHuang, F.
dc.contributor.authorChen, C.C.
dc.contributor.authorYuan, X.
dc.contributor.authorTokuzaki, K.
dc.contributor.authorTomiyama, H.
dc.contributor.authorLinhardt, Robert J.
dc.date2008
dc.date.accessioned2022-06-27T16:11:45Z
dc.date.available2022-06-27T16:11:45Z
dc.date.issued2008-09-01
dc.identifier.citationSynthesis and Evaluation of Anticancer Vaccine Candidate, C-Glycoside Analogs of sTn and PSA, M. Weïwer, F. Huang, C.-C. Chen, X. Yuan, K. Tokuzaki, H. Tomiyama, R. J. Linhardt, Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, X. Chen, R. L. Halcomb, p. G. Wang, Eds., ACS Press, Chap. 10, pp. 175-195, 2008.
dc.identifier.issn19475918
dc.identifier.issn976156
dc.identifier.urihttps://doi.org/10.1021/bk-2008-0990.ch010
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5761
dc.descriptionChemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, X. Chen, R. L. Halcomb, p. G. Wang, Eds., ACS Press, Chap. 10, pp. 175-195
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractNeuraminic acids are biologically important and occupy the terminal position of the glycoconjugate glycans on the outside of cells. Sialyl-Tn (sTn) is found on tumor-associated glycoprotein antigens present on the surface of cancer cells, including those associated with carcinomas of the breast, prostate, pancreas, colon, ovary, lung, and stomach. The sTn antigen is well known as a prognostic indicator and has proven to be an effective target for cancer therapy. Conjugate vaccines of sTn-KLH show remarkable immunogenicity, resulting in the production of both IgM and IgG type antibodies. The sTn Cglycoside was designed and synthesized and its KLH-conjugate was evaluated for immunogenicity in mice. Neuraminic acid C-glycosides such as sTn and polysialic acid (PSA) might be useful in preparing immunogens for active immunization against neuraminic acid containing glycoconjugates in the design and preparation of anti-cancer vaccines.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/bk-2008-0990.ch010
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofACS Symposium Series
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSynthesis and Evaluation of Anticancer Vaccine Candidate, C-Glycoside Analogs of sTn and PSA
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/bk-2008-0990.ch010
dcterms.isPartOfBook Series
dcterms.isVersionOfhttps://doi.org/10.1021/bk-2008-0990.ch010
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages216-238
rpi.description.volume990


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