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dc.contributor.authorZhang, Zhenqing
dc.contributor.authorXie, Jin
dc.contributor.authorLiu, Jian
dc.contributor.authorLinhardt, Robert J.
dc.date2008
dc.date.accessioned2022-06-27T16:11:45Z
dc.date.available2022-06-27T16:11:45Z
dc.date.issued2008-01-01
dc.identifier.citationTandem MS Can Distinguish Hyaluronic Acid from N-Acetylheparosan, Z. Zhang, J. Xie, J. Liu, R. J. Linhardt, Journal of American Society of Mass Spectrometry, 19, 82-89, 2008.
dc.identifier.issn10440305
dc.identifier.urihttps://doi.org/10.1016/j.jasms.2007.10.012
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5762
dc.descriptionJournal of American Society of Mass Spectrometry, 19, 82-89
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractIsobaric oligosaccharides enzymatically prepared from hyaluronic acid (HA) and N-acetylheparosan (NAH), were distinguished using tandem mass spectrometry. The only difference between the two series of oligosaccharides was the linkage pattern (in HA 1→3 and in NAH 1→4) between glucuronic acid and N-acetylglucosamine residues. Tandem mass spectrometry afforded spectra in which glycosidic cleavage fragment ions were observed for both HA and NAH oligosaccharides. Cross-ring cleavage ions 0,2An and 0,2An-h (n is even number) were observed only in GlcNAc residues of NAH oligosaccharides. One exception was an 0,2A2 ion fragment observed for the disaccharide from HA. These cross-ring cleavage fragment ions are useful to definitively distinguish HA and NAH oligosaccharides.
dc.description.sponsorshipNational Institutes of Health
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.jasms.2007.10.012
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofJournal of the American Society for Mass Spectrometry
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleTandem MS Can Distinguish Hyaluronic Acid from N-Acetylheparosan
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.jasms.2007.10.012
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/j.jasms.2007.10.012
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages82-90
rpi.description.volume19


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