dc.contributor.author | Zhang, Zhenqing | |
dc.contributor.author | Xie, Jin | |
dc.contributor.author | Liu, Jian | |
dc.contributor.author | Linhardt, Robert J. | |
dc.date | 2008 | |
dc.date.accessioned | 2022-06-27T16:11:45Z | |
dc.date.available | 2022-06-27T16:11:45Z | |
dc.date.issued | 2008-01-01 | |
dc.identifier.citation | Tandem MS Can Distinguish Hyaluronic Acid from N-Acetylheparosan, Z. Zhang, J. Xie, J. Liu, R. J. Linhardt, Journal of American Society of Mass Spectrometry, 19, 82-89, 2008. | |
dc.identifier.issn | 10440305 | |
dc.identifier.uri | https://doi.org/10.1016/j.jasms.2007.10.012 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13015/5762 | |
dc.description | Journal of American Society of Mass Spectrometry, 19, 82-89 | |
dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
dc.description.abstract | Isobaric oligosaccharides enzymatically prepared from hyaluronic acid (HA) and N-acetylheparosan (NAH), were distinguished using tandem mass spectrometry. The only difference between the two series of oligosaccharides was the linkage pattern (in HA 1→3 and in NAH 1→4) between glucuronic acid and N-acetylglucosamine residues. Tandem mass spectrometry afforded spectra in which glycosidic cleavage fragment ions were observed for both HA and NAH oligosaccharides. Cross-ring cleavage ions 0,2An and 0,2An-h (n is even number) were observed only in GlcNAc residues of NAH oligosaccharides. One exception was an 0,2A2 ion fragment observed for the disaccharide from HA. These cross-ring cleavage fragment ions are useful to definitively distinguish HA and NAH oligosaccharides. | |
dc.description.sponsorship | National Institutes of Health | |
dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.jasms.2007.10.012 | |
dc.language | en_US | |
dc.language.iso | ENG | |
dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
dc.relation.ispartof | Journal of the American Society for Mass Spectrometry | |
dc.relation.uri | https://harc.rpi.edu/ | |
dc.subject | Biology | |
dc.subject | Chemistry and chemical biology | |
dc.subject | Chemical and biological engineering | |
dc.subject | Biomedical engineering | |
dc.title | Tandem MS Can Distinguish Hyaluronic Acid from N-Acetylheparosan | |
dc.type | Article | |
dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/j.jasms.2007.10.012 | |
dcterms.isPartOf | Journal | |
dcterms.isVersionOf | https://doi.org/10.1016/j.jasms.2007.10.012 | |
dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
dc.relation.department | The Linhardt Research Labs. | |
dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
rpi.description.pages | 82-90 | |
rpi.description.volume | 19 | |