Author
Weiwer, M.; Linhardt, Robert J.
Other Contributors
Date Issued
2007
Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
Degree
Terms of Use
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Full Citation
Synthesis of Glycosaminoglycans and their Oligosaccharides, M. Weiwer, R. J. Linhardt, in Comprehensive Glycosciences, G. J. Boons, Y. C. Lee, A. Suzuki, N. Taniguchi, A. G. J. Voragen, J.P. Kamerling (eds.) Elsevier BV, Amsterdam, The Netherlands, Chap 1.18, 713-745, 2007.
Abstract
Glycosaminoglycans, highly charged polycarboxylated, polysulfated polysaccharides, are an important class of therapeutic agents and investigational drug candidates. Heparin has been widely used as a clinical anticoagulant for over 60 years. Low molecular weight heparins have begun to displace heparin and recently a synthetic heparin pentasaccharide was approved for clinical use in Europe. In addition to heparin (and the related heparan sulfate glycosaminoglycan), dermatan sulfate, chondroitin sulfate, hyaluronan and their derivatives are all in various stages of clinical evaluation. This review focuses on the chemical and chemoenzymatic synthesis of glycosaminoglycan oligosaccharides. Recent advances in functional group protection chemistry, conversion of D-gluco to L-ido or D-galacto configurations, glycosylation reactions and the preparation and use of novel starting materials in acidic oligosaccharide synthesis are discussed.;
Description
in Comprehensive Glycosciences, G. J. Boons, Y. C. Lee, A. Suzuki, N. Taniguchi, A. G. J. VoragenJ.P. Kamerling (eds.) Elsevier BV, Amsterdam, The Netherlands, Chap 1.18, 713-745; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Relationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
Access
https://login.libproxy.rpi.edu/login?url=http://dx.doi.org/10.2174/0929867033456891;
