Author
Avci, Fikri Y.; DeAngelis, Paul L.; Liu, Jian; Linhardt, Robert J.
Other Contributors
Date Issued
2007-01-01
Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
Degree
Terms of Use
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Full Citation
Enzymatic Synthesis of Glycosaminoglycans: Improving on Nature, F.Y. Avci, P.L. DeAngelis, J. Liu, R.J. Linhardt, in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, 2007, Oxford University Press, London.
Abstract
The chemoenzymatic synthesis of glycosaminoglycan (GAG) analogs is described. This chapter is divided into three main sections, each describing the use of one enzyme family in GAG synthesis. First, the polysaccharide lyase enzymes are described. These enzymes play crucial role in obtaining GAG oligosaccharides. Second, GAG synthases, bacterial enzymes that transfer UDP-monosaccharides to acceptor oligosaccharide are described, to obtain homogenous oligosaccahrides and polysaccharides. Finally, GAG sulfotransferases, that play a major role in the biosynthesis, are described for the introduction of sulfo groups to the appropriate positions on the polysaccharide backbone.;
Description
in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, Oxford University Press, London; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Relationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; ACS Symposium Series; https://harc.rpi.edu/;
Access
https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/bk-2007-0960.ch015;
