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dc.contributor.authorAvci, Fikri Y.
dc.contributor.authorDeAngelis, Paul L.
dc.contributor.authorLiu, Jian
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationEnzymatic Synthesis of Glycosaminoglycans: Improving on Nature, F.Y. Avci, P.L. DeAngelis, J. Liu, R.J. Linhardt, in Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, 2007, Oxford University Press, London.
dc.descriptionin Frontiers in Carbohydrate Chemistry, ACS Symposium Series 960, A. Demchenko, Ed., Chapter 15, pp 253-284, Oxford University Press, London
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractThe chemoenzymatic synthesis of glycosaminoglycan (GAG) analogs is described. This chapter is divided into three main sections, each describing the use of one enzyme family in GAG synthesis. First, the polysaccharide lyase enzymes are described. These enzymes play crucial role in obtaining GAG oligosaccharides. Second, GAG synthases, bacterial enzymes that transfer UDP-monosaccharides to acceptor oligosaccharide are described, to obtain homogenous oligosaccahrides and polysaccharides. Finally, GAG sulfotransferases, that play a major role in the biosynthesis, are described for the introduction of sulfo groups to the appropriate positions on the polysaccharide backbone.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofACS Symposium Series
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleEnzymatic Synthesis of Glycosaminoglycans: Improving on Nature
dc.typeBook chapter
dcterms.isPartOfBook Series
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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