Role of Glycosaminoglycans in Cellular Communication

Authors
Linhardt, Robert J.
Toida, Toshihiko
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2004-07-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Role of Glycosaminoglycans in Cellular Communication, R. J. Linhardt, T. Toida, Accounts of Chemical Research, 37, 431-438, 2004.
Abstract
Glycosaminoglycans are of critical importance in intercellular communication in organisms. This ubiquitous class of linear polyanions interacts with a wide variety of proteins, including growth factors and chemokines, which regulate important physiological processes. The presence of glycosaminoglycans on cell membranes and in the extracellular matrix also has resulted in their exploitation by infectious pathogens to gain access and entry into animal cells. This Account examines the structural and physical characteristics of these molecules responsible for their interaction with proteins important in cell−cell communication.
Description
Accounts of Chemical Research, 37, 431-438
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Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Accounts of Chemical Research
https://harc.rpi.edu/
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https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/ar030138x