Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties
Authors
Avci, Fikri Y.
Karst, Nathalie A.
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2003-10-21
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Synthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties, F. Y. Avci, N. A. Karst, R. J. Linhardt, Current Pharmaceutical Design, 9, 2323-2335, 2003.
Abstract
Heparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep venous thrombosis. The discovery of an antithrombin binding domain in heparin focused interest on understanding the mechanism of heparin's antithrombotic/ anticoagulant activity. Various heparin-mimetic oligosaccharides have been prepared in an effort to replace polydisperse heparin and low molecular weight heparins with a structurally-defined anticoagulant. The goal of attaining a heparin-mimetic with no unwanted side-effects has also provided motivation for these efforts. This article reviews structure-activity relationship (SAR) of structurally-defined heparin-mimetic oligosaccharides.
Description
Current Pharmaceutical Design, 9, 2323-2335
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Current Pharmaceutical Design
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
Current Pharmaceutical Design
https://harc.rpi.edu/
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https://login.libproxy.rpi.edu/login?url=https://doi.org/10.2174/1381612033453929