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dc.contributor.authorAvci, Fikri Y.
dc.contributor.authorKarst, Nathalie A.
dc.contributor.authorLinhardt, Robert J.
dc.date2003
dc.date.accessioned2022-06-27T16:16:41Z
dc.date.available2022-06-27T16:16:41Z
dc.date.issued2003-10-21
dc.identifier.citationSynthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties, F. Y. Avci, N. A. Karst, R. J. Linhardt, Current Pharmaceutical Design, 9, 2323-2335, 2003.
dc.identifier.issn13816128
dc.identifier.urihttps://doi.org/10.2174/1381612033453929
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5804
dc.descriptionCurrent Pharmaceutical Design, 9, 2323-2335
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin and low molecular weight heparins are major clinical anticoagulants and the drugs of choice for the treatment of deep venous thrombosis. The discovery of an antithrombin binding domain in heparin focused interest on understanding the mechanism of heparin's antithrombotic/ anticoagulant activity. Various heparin-mimetic oligosaccharides have been prepared in an effort to replace polydisperse heparin and low molecular weight heparins with a structurally-defined anticoagulant. The goal of attaining a heparin-mimetic with no unwanted side-effects has also provided motivation for these efforts. This article reviews structure-activity relationship (SAR) of structurally-defined heparin-mimetic oligosaccharides.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.2174/1381612033453929
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCurrent Pharmaceutical Design
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSynthetic Oligosaccharides as Heparin-Mimetics Displaying Anticoagulant Properties
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.2174/1381612033453929
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dcterms.isVersionOfhttps://doi.org/10.2174/1381612033453929
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages2323-2335
rpi.description.volume9


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