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dc.contributor.authorKarst, Nathalie A.
dc.contributor.authorLinhardt, Robert J.
dc.date2003
dc.date.accessioned2022-06-27T16:16:41Z
dc.date.available2022-06-27T16:16:41Z
dc.date.issued2003-09-29
dc.identifier.citationRecent Chemical and Enzymatic Approaches to the Synthesis of Glycosaminoglycan Oligosaccharides, N.A. Karst, R.J. Linhardt, Current Medicinal Chemistry, 10, 1993-2031, 2003.
dc.identifier.issn9298673
dc.identifier.urihttps://doi.org/10.2174/0929867033456891
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5807
dc.descriptionCurrent Medicinal Chemistry, 10, 1993-2031
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractGlycosaminoglycans, highly charged polycarboxylated, polysulfated polysaccharides, are an important class of therapeutic agents and investigational drug candidates. Heparin has been widely used as a clinical anticoagulant for over 60 years. Low molecular weight heparins have begun to displace heparin and recently a synthetic heparin pentasaccharide was approved for clinical use in Europe. In addition to heparin (and the related heparan sulfate glycosaminoglycan), dermatan sulfate, chondroitin sulfate, hyaluronan and their derivatives are all in various stages of clinical evaluation. This review focuses on the chemical and chemoenzymatic synthesis of glycosaminoglycan oligosaccharides. Recent advances in functional group protection chemistry, conversion of D-gluco to L-ido or D-galacto configurations, glycosylation reactions and the preparation and use of novel starting materials in acidic oligosaccharide synthesis are discussed.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.2174/0929867033456891
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCurrent Medicinal Chemistry
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleRecent Chemical and Enzymatic Approaches to the Synthesis of Glycosaminoglycan Oligosaccharides
dc.typeArticle
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dcterms.isVersionOfhttps://doi.org/10.2174/0929867033456891
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages1993-2031
rpi.description.volume10


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