Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Structure and Bioactivity of Sulfated Polysaccharides, T. Toida, R.J. Linhardt, Trends in Glycosciences and Glycotechnology, 15, 29-46, 2003.
Sulfated polysaccharides including glycosaminoglycans show various chemical and biological functions. These functions strongly depend on the presence and spatial positioning of their sulfo groups. Therefore, chemical modifications such as partial, per-O-sulfonation or desulfonation are expected to alter the function of sulfated polysaccharides. There are many reports on the chemical modification of polysaccharides. This paper focuses on the investigation of both the chemical modification of polysaccharides and its effect biological function. A structure-activity relationship, SAR, is established on both intact and chemically modified polysaccharides.;
Trends in Glycosciences and Glycotechnology, 15, 29-46; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;