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    Structure and Bioactivity of Sulfated Polysaccharides

    酸性多糖類の構造と生理活性

    Author
    Toida, T.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Other Contributors
    Date Issued
    2003
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Structure and Bioactivity of Sulfated Polysaccharides, T. Toida, R.J. Linhardt, Trends in Glycosciences and Glycotechnology, 15, 29-46, 2003.
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    URI
    https://doi.org/10.4052/tigg.15.29; https://hdl.handle.net/20.500.13015/5808
    Abstract
    Sulfated polysaccharides including glycosaminoglycans show various chemical and biological functions. These functions strongly depend on the presence and spatial positioning of their sulfo groups. Therefore, chemical modifications such as partial, per-O-sulfonation or desulfonation are expected to alter the function of sulfated polysaccharides. There are many reports on the chemical modification of polysaccharides. This paper focuses on the investigation of both the chemical modification of polysaccharides and its effect biological function. A structure-activity relationship, SAR, is established on both intact and chemically modified polysaccharides.;
    Description
    Trends in Glycosciences and Glycotechnology, 15, 29-46; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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