dc.contributor.author | Gunay, N.S. | |
dc.contributor.author | Tadano-Aritomi, K. | |
dc.contributor.author | Toida, T. | |
dc.contributor.author | Ishizuka, I. | |
dc.contributor.author | Linhardt, Robert J. | |
dc.date | 2003 | |
dc.date.accessioned | 2022-06-27T16:18:37Z | |
dc.date.available | 2022-06-27T16:18:37Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Evaluation of Counter-Ions for Electrospray Ionization Mass Spectral Analysis of Highly Sulfated Carbohydrates, N.S. Gunay, K. Tadano-Aritomi, T. Toida, I. Ishizuka, R.J. Linhardt, Analytical Chemistry, 75, 3226-3231, 2003. | |
dc.identifier.uri | https://doi.org/10.1021/ac034053l | |
dc.identifier.uri | https://hdl.handle.net/20.500.13015/5811 | |
dc.description | Analytical Chemistry, 75, 3226-3231 | |
dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
dc.description.abstract | A systematic approach was used to evaluate the electrospray ionization mass spectral (ESI-MS) analysis of sucrose octasulfate (SOS), an important pharmaceutical agent. SOS represents a model for other suffated carbohydrates, such as heparin and glycosaminoglycan-derived oligosaccharides that also are highly sulfated and pose difficult analytical problems. A survey of ammonium counterions showed that 1 degree, 2 degrees, and 3 degrees ammonium salts of SOS gave substantial fragmentation as a result of sulfate loss. In contrast, quaternary ammonium and phosphonium salts gave excellent ESI spectra, particularly in the positive ion mode. This represents the first report of the ESI-MS analysis of sulfated carbohydrates in the positive ion mode. | |
dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/ac034053l | |
dc.language | en_US | |
dc.language.iso | ENG | |
dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
dc.relation.uri | https://harc.rpi.edu/ | |
dc.subject | Biology | |
dc.subject | Chemistry and chemical biology | |
dc.subject | Chemical and biological engineering | |
dc.subject | Biomedical engineering | |
dc.title | Evaluation of Counter-Ions for Electrospray Ionization Mass Spectral Analysis of Highly Sulfated Carbohydrates | |
dc.type | Article | |
dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/ac034053l | |
dcterms.isVersionOf | https://doi.org/10.1021/ac034053l | |
dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
dc.relation.department | The Linhardt Research Labs. | |
dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |