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dc.contributor.authorGunay, N.S.
dc.contributor.authorTadano-Aritomi, K.
dc.contributor.authorToida, T.
dc.contributor.authorIshizuka, I.
dc.contributor.authorLinhardt, Robert J.
dc.date2003
dc.date.accessioned2022-06-27T16:18:37Z
dc.date.available2022-06-27T16:18:37Z
dc.date.issued2003
dc.identifier.citationEvaluation of Counter-Ions for Electrospray Ionization Mass Spectral Analysis of Highly Sulfated Carbohydrates, N.S. Gunay, K. Tadano-Aritomi, T. Toida, I. Ishizuka, R.J. Linhardt, Analytical Chemistry, 75, 3226-3231, 2003.
dc.identifier.urihttps://doi.org/10.1021/ac034053l
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5811
dc.descriptionAnalytical Chemistry, 75, 3226-3231
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractA systematic approach was used to evaluate the electrospray ionization mass spectral (ESI-MS) analysis of sucrose octasulfate (SOS), an important pharmaceutical agent. SOS represents a model for other suffated carbohydrates, such as heparin and glycosaminoglycan-derived oligosaccharides that also are highly sulfated and pose difficult analytical problems. A survey of ammonium counterions showed that 1 degree, 2 degrees, and 3 degrees ammonium salts of SOS gave substantial fragmentation as a result of sulfate loss. In contrast, quaternary ammonium and phosphonium salts gave excellent ESI spectra, particularly in the positive ion mode. This represents the first report of the ESI-MS analysis of sulfated carbohydrates in the positive ion mode.
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/ac034053l
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleEvaluation of Counter-Ions for Electrospray Ionization Mass Spectral Analysis of Highly Sulfated Carbohydrates
dc.typeArticle
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dcterms.isVersionOfhttps://doi.org/10.1021/ac034053l
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dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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