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dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorToida, Toshihiko
dc.identifier.citationCharacterization of Glycosaminoglycans by Capillary Electrophoresis, R.J. Linhardt, T. Toida, in Capillary Electrophoresis of Oligosaccharides and Complex Carbohydrates, S. Honda, P. Thibault, Eds. Humana Press, Totawa, NJ, 133-146, 2002.
dc.descriptionin Capillary Electrophoresis of Oligosaccharides and Complex Carbohydrates, S. Honda, P. Thibault, Eds. Humana Press, Totawa, NJ, 133-146
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractGlycosaminoglycans are linear, sulfated polysaccharides that are found in virtually all animal tissues. With the exception of hyaluronic acid, glycosaminoglycans are biosynthesized as proteoglycans in which one or more glycosaminoglycan chains are attached to a core protein (1). Chondroitin and dermatan sulfates are comprised of alternating 1→3, 1→4 linked N-acetyl-D-galactosamine and hexuronic acid (either D-glucuronic or L-iduronic acid) residues. These saccharide residues can be O-sulfonated at various positions on both sugar residues. Heparin and heparan sulfate are structurally related and are comprised of a hexuronic acid residue (either L-iduronic or D-glucuronic acid) 1→4 linked to a D-glucosamine (either N-sulfo or N-acetyl-D-glucosamine) residue. Both saccharide residues can be O-sulfonated at a variety of different positions, making these glycosaminoglycans structurally complex. Hyaluronic acid contains a simple repeating structure of 1→3, 1→4 linked N-acetyl-D-glucosamine and D-glucuronic acid residues. Hyaluronic acid is an unusual glycosaminoglycan as it is not sulfonated and can have a very high molecular weight, up to 2 × 106 Da compared to 1–3 × 105 for the other glycosaminoglycans. Keratan sulfate is a glycosaminoglycan that contains no uronic acid and is comprised of a repeating 1→3, 1→4 linked, O-sulfonated N-acetyl-D-glu-cosamine and D-galactose residues.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofMethods in molecular biology (Clifton, N.J.)
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleCharacterization of Glycosaminoglycans by Capillary Electrophoresis
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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