Ultra-High Resolution Separation Comes of Age
Authors
Linhardt, Robert J.
Toida, Toshihiko
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
2002-11-15
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Ultra-High Resolution Separation Comes of Age, R.J. Linhardt, T. Toida, Science, 298, 1141-1142, 2002.
Abstract
Born in the late 1960s (1), popularized in its infancy for its high resolution (2), and reaching puberty in the mid 1980s with the introduction of commercial instrumentation (3), capillary electrophoresis (CE) has finally entered adulthood as a reliable and widely useful analytical technology. In 1937, Nobel Prize-winner Arne Tiselius first described electrophoresis, a method for separating charged molecules in an externally applied electric field. With the introduction of agarose and polyacrylamide gels, electrophoresis evolved as the principal means of high-resolution biopolymer (e.g., DNA, protein, and glycan) analysis. Gel electrophoresis, however, remains a qualitative, time-consuming, and labor-intensive analytical method. As we enter the new millennium, we have begun to realize the potential of CE for the automated and rapid analysis of complex mixtures with high resolution and high sensitivity.
Description
Science, 298, 1141-1142
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Science
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
Science
https://harc.rpi.edu/
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