dc.contributor.author | Linhardt, Robert J. | |
dc.contributor.author | Toida, Toshihiko | |
dc.date | 2002 | |
dc.date.accessioned | 2022-06-27T16:18:37Z | |
dc.date.available | 2022-06-27T16:18:37Z | |
dc.date.issued | 2002-11-15 | |
dc.identifier.citation | Ultra-High Resolution Separation Comes of Age, R.J. Linhardt, T. Toida, Science, 298, 1141-1142, 2002. | |
dc.identifier.issn | 368075 | |
dc.identifier.uri | https://doi.org/10.1126/science.298.5597.1441 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13015/5819 | |
dc.description | Science, 298, 1141-1142 | |
dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
dc.description.abstract | Born in the late 1960s (1), popularized in its infancy for its high resolution (2), and reaching puberty in the mid 1980s with the introduction of commercial instrumentation (3), capillary electrophoresis (CE) has finally entered adulthood as a reliable and widely useful analytical technology. In 1937, Nobel Prize-winner Arne Tiselius first described electrophoresis, a method for separating charged molecules in an externally applied electric field. With the introduction of agarose and polyacrylamide gels, electrophoresis evolved as the principal means of high-resolution biopolymer (e.g., DNA, protein, and glycan) analysis. Gel electrophoresis, however, remains a qualitative, time-consuming, and labor-intensive analytical method. As we enter the new millennium, we have begun to realize the potential of CE for the automated and rapid analysis of complex mixtures with high resolution and high sensitivity. | |
dc.description.sponsorship | National Heart, Lung, and Blood Institute | |
dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1126/science.298.5597.1441 | |
dc.language | en_US | |
dc.language.iso | ENG | |
dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
dc.relation.ispartof | Science | |
dc.relation.uri | https://harc.rpi.edu/ | |
dc.subject | Biology | |
dc.subject | Chemistry and chemical biology | |
dc.subject | Chemical and biological engineering | |
dc.subject | Biomedical engineering | |
dc.title | Ultra-High Resolution Separation Comes of Age | |
dc.type | Article | |
dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1126/science.298.5597.1441 | |
dcterms.isPartOf | Journal | |
dcterms.isVersionOf | https://doi.org/10.1126/science.298.5597.1441 | |
dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
dc.relation.department | The Linhardt Research Labs. | |
dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
rpi.description.pages | 1441-1442 | |
rpi.description.volume | 298 | |