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    Preparation and anticoagulant activity of phosphosulfomannan PI-88

    Author
    Yu, Guangli; Gunay, Nur Sibel; Linhardt, Robert J.; Toida, Toshihiko; Fareed, Jawed; Hoppensteadt, Debra A.; Shadid, Hazar; Ferro, Vito; Li, Caiping; Fewings, Kym; Palermo, Maria C.; Podger, Denis
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Other Contributors
    Date Issued
    2002-10-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Preparation and anticoagulant activity of phosphosulfomannan PI-88, G. Yu, N.S Gunay, R.J Linhardt, T. Toida, J. Fareed, D.A. Hoppensteadt, H. Shadid, V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, European Journal of Medicinal Chemistry, 37, 783-791, 2002.
    Metadata
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    URI
    https://doi.org/10.1016/S0223-5234(02)01347-8; https://hdl.handle.net/20.500.13015/5822
    Abstract
    A yeast-derived phosphomannan mixture was chemically sulfonated and the composition and structure of the product mixture was studied. This phosphosulfomannan mixture, PI-88, is currently under clinical evaluation as an anti-cancer agent. Analysis using capillary electrophoresis demonstrated that PI-88 was a multi-component mixture. Gel permeation chromatography provided four fractions of PI-88 that contained components which differed in size from disaccharide to hexasaccharide, and by degree of sulfation. These fractions were characterised by spectroscopic and chromatographic methods and the structure of PI-88 is that expected based on the structure of the phosphomannan starting material. The anticoagulant activity of these fractions was evaluated and the structural requirements for activity are described.;
    Description
    European Journal of Medicinal Chemistry, 37, 783-791; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; European Journal of Medicinal Chemistry; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0223-5234(02)01347-8;
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