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dc.contributor.authorYu, Guangli
dc.contributor.authorGunay, Nur Sibel
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorToida, Toshihiko
dc.contributor.authorFareed, Jawed
dc.contributor.authorHoppensteadt, Debra A.
dc.contributor.authorShadid, Hazar
dc.contributor.authorFerro, Vito
dc.contributor.authorLi, Caiping
dc.contributor.authorFewings, Kym
dc.contributor.authorPalermo, Maria C.
dc.contributor.authorPodger, Denis
dc.identifier.citationPreparation and anticoagulant activity of phosphosulfomannan PI-88, G. Yu, N.S Gunay, R.J Linhardt, T. Toida, J. Fareed, D.A. Hoppensteadt, H. Shadid, V. Ferro, C. Li, K. Fewings, M.C. Palermo, D. Podger, European Journal of Medicinal Chemistry, 37, 783-791, 2002.
dc.descriptionEuropean Journal of Medicinal Chemistry, 37, 783-791
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractA yeast-derived phosphomannan mixture was chemically sulfonated and the composition and structure of the product mixture was studied. This phosphosulfomannan mixture, PI-88, is currently under clinical evaluation as an anti-cancer agent. Analysis using capillary electrophoresis demonstrated that PI-88 was a multi-component mixture. Gel permeation chromatography provided four fractions of PI-88 that contained components which differed in size from disaccharide to hexasaccharide, and by degree of sulfation. These fractions were characterised by spectroscopic and chromatographic methods and the structure of PI-88 is that expected based on the structure of the phosphomannan starting material. The anticoagulant activity of these fractions was evaluated and the structural requirements for activity are described.
dc.description.sponsorshipNational Institutes of Health
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofEuropean Journal of Medicinal Chemistry
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titlePreparation and anticoagulant activity of phosphosulfomannan PI-88
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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