Author
Zhang, Fuming; Fath, Melissa; Marks, Rory; Linhardt, Robert J.
Other Contributors
Date Issued
2002-05-15
Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
Degree
Terms of Use
In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
Full Citation
A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies, F. Zhang, M. Fath, R. Marks, R.J. Linhardt, Analytical Biochemistry, 304, 271-273, 2002.
Abstract
Heparin is a proteoglycan composed of highly sulfated linear polysaccharides of alternating uronic acid and glucosamine that interacts with a wide variety of proteins and peptides (1). Heparin and the structurally related heparan sulfate are the most acidic polysaccarides in the human body and, as a result, interact with many cationic proteins, giving rise to myriad biological activities (2). Some of these interactions have received extensive attention in recent years, including heparin’s binding to growth factors (3, 4) influencing angiogenesis and other proliferation-dependent processes, and its binding to the ectodomain proteins of pathogens influencing infection.;
Description
Analytical Biochemistry, 304, 271-273; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Relationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Analytical Biochemistry; https://harc.rpi.edu/;
Access
https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1006/abio.2002.5617;
