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    A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies

    Author
    Zhang, Fuming; Fath, Melissa; Marks, Rory; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Other Contributors
    Date Issued
    2002-05-15
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    A Highly Stable Covalent Conjugated Heparin Biochip for Heparin-Protein Interactions Studies, F. Zhang, M. Fath, R. Marks, R.J. Linhardt, Analytical Biochemistry, 304, 271-273, 2002.
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    URI
    https://doi.org/10.1006/abio.2002.5617; https://hdl.handle.net/20.500.13015/5829
    Abstract
    Heparin is a proteoglycan composed of highly sulfated linear polysaccharides of alternating uronic acid and glucosamine that interacts with a wide variety of proteins and peptides (1). Heparin and the structurally related heparan sulfate are the most acidic polysaccarides in the human body and, as a result, interact with many cationic proteins, giving rise to myriad biological activities (2). Some of these interactions have received extensive attention in recent years, including heparin’s binding to growth factors (3, 4) influencing angiogenesis and other proliferation-dependent processes, and its binding to the ectodomain proteins of pathogens influencing infection.;
    Description
    Analytical Biochemistry, 304, 271-273; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Analytical Biochemistry; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1006/abio.2002.5617;
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