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Heparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site

dc.contributor.authorYu, Guangli
dc.contributor.authorLeBrun, Laurie
dc.contributor.authorGunay, Nur Sibel
dc.contributor.authorHoppensteadt, Debra
dc.contributor.authorWalenga, Jeanine M.
dc.contributor.authorFareed, Jawed
dc.contributor.authorLinhardt, Robert J.
dc.date2000
dc.date.accessioned2022-06-27T16:20:27Z
dc.date.available2022-06-27T16:20:27Z
dc.date.issued2000-12-15
dc.identifier.citationHeparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site, G. Yu, L. LeBrun, N.S. Gunay, D. Hoppensteadt, J. Walenga, J. Fareed, R.J. Linhardt, Thrombosis Research, 100, 549-556, 2000.
dc.identifier.issn493848
dc.identifier.urihttps://doi.org/10.1016/S0049-3848(00)00368-6
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5863
dc.descriptionThrombosis Research, 100, 549-556
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractA synthetic pentasaccharide, containing an intact antithrombin III (ATIII) binding site that is in clinical studies a specific antifactor Xa agent, serves as a substrate for a heparin lyase (heparinase I, EC 4.2.2.7) from Flavobacterium heparinum. Heparinase I, currently being assessed as a heparin reversal agent, also reverses the antifactor Xa activity of this synthetic pentasaccharide by breaking it down to inactive disaccharide and trisaccharide products.
dc.description.sponsorshipNational Institutes of Health
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0049-3848(00)00368-6
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofThrombosis Research
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleHeparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site
dc.typeArticle
dcterms.accessRightshttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0049-3848(00)00368-6
dcterms.isPartOfJournal
dcterms.isVersionOfhttps://doi.org/10.1016/S0049-3848(00)00368-6
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
rpi.description.pages549-556
rpi.description.volume100


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