dc.contributor.author | Yu, Guangli | |
dc.contributor.author | LeBrun, Laurie | |
dc.contributor.author | Gunay, Nur Sibel | |
dc.contributor.author | Hoppensteadt, Debra | |
dc.contributor.author | Walenga, Jeanine M. | |
dc.contributor.author | Fareed, Jawed | |
dc.contributor.author | Linhardt, Robert J. | |
dc.date | 2000 | |
dc.date.accessioned | 2022-06-27T16:20:27Z | |
dc.date.available | 2022-06-27T16:20:27Z | |
dc.date.issued | 2000-12-15 | |
dc.identifier.citation | Heparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site, G. Yu, L. LeBrun, N.S. Gunay, D. Hoppensteadt, J. Walenga, J. Fareed, R.J. Linhardt, Thrombosis Research, 100, 549-556, 2000. | |
dc.identifier.issn | 493848 | |
dc.identifier.uri | https://doi.org/10.1016/S0049-3848(00)00368-6 | |
dc.identifier.uri | https://hdl.handle.net/20.500.13015/5863 | |
dc.description | Thrombosis Research, 100, 549-556 | |
dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
dc.description.abstract | A synthetic pentasaccharide, containing an intact antithrombin III (ATIII) binding site that is in clinical studies a specific antifactor Xa agent, serves as a substrate for a heparin lyase (heparinase I, EC 4.2.2.7) from Flavobacterium heparinum. Heparinase I, currently being assessed as a heparin reversal agent, also reverses the antifactor Xa activity of this synthetic pentasaccharide by breaking it down to inactive disaccharide and trisaccharide products. | |
dc.description.sponsorship | National Institutes of Health | |
dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0049-3848(00)00368-6 | |
dc.language | en_US | |
dc.language.iso | ENG | |
dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
dc.relation.ispartof | Thrombosis Research | |
dc.relation.uri | https://harc.rpi.edu/ | |
dc.subject | Biology | |
dc.subject | Chemistry and chemical biology | |
dc.subject | Chemical and biological engineering | |
dc.subject | Biomedical engineering | |
dc.title | Heparinase I Acts on a Synthetic Heparin Pentasaccharide Corresponding to the Antithrombin III Binding Site | |
dc.type | Article | |
dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0049-3848(00)00368-6 | |
dcterms.isPartOf | Journal | |
dcterms.isVersionOf | https://doi.org/10.1016/S0049-3848(00)00368-6 | |
dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
dc.relation.department | The Linhardt Research Labs. | |
dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
rpi.description.pages | 549-556 | |
rpi.description.volume | 100 | |