Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Electrophoresis for the Analysis of Acidic Oligosaccharides, M. Koketsu, R.J. Linhardt, Analytical Biochemistry, 283, 136-145, 2000.
Carbohydrates are the most abundant species among the biopolymers and have recently been actively studied as important biological molecules (1). Acidic oligosaccharides play especially important biological roles, including control of cell proliferation, differentiation (2, 3), adhesion (4, 5), migration (6), morphological regulation (7, 8) during development (9), blood coagulation (10 –12), virus and bacterial infection (13), and tumor malignancy (14). These functions are regulated by the subtle differences in oligosaccharide structure. Heparin, for example, contains a specific pentasaccharide sequence, containing a rare 3-O-sulfo glucosamine residue, that is essential for antithrombin III binding, resulting in anticoagulation (15).;
Analytical Biochemistry, 283, 136-145; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Analytical Biochemistry; https://harc.rpi.edu/;