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    Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides

    Author
    Wang, Qun; Wolff, Michael; Polat, Tülay; Du, Yuguo; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Other Contributors
    Date Issued
    2000-05-01
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Inhibition of Neuraminidase with Neuraminic Acid C-Glycosides, Q. Wang, M. Wolff, T. Polat, R.J. Linhardt, Bioorganic & Medicinal Chemistry Letters, 10, 941-944, 2000.
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    URI
    https://doi.org/10.1016/S0960-894X(00)00132-3; https://hdl.handle.net/20.500.13015/5870
    Abstract
    Neuraminic (sialic) acid based alpha-C-glycosides have been synthesized and their inhibitory activity towards bacterial neuraminidase (sialidase) was examined. While some C-glycosides were found to be potent inhibitors (Ki 15-30 microM) of this neuraminidase, others afforded no measurable activity. The structure-activity relationship of these C-glycosides is discussed in the context of other previously reported sialidase inhibitors.;
    Description
    Bioorganic & Medicinal Chemistry Letters, 10, 941-944; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Bioorganic and Medicinal Chemistry Letters; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0960-894X(00)00132-3;
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