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dc.contributor.authorGarg, H.G.
dc.contributor.authorJoseph, P.A.M.
dc.contributor.authorThompson, T.
dc.contributor.authorHales, C.A.
dc.contributor.authorToida, T.
dc.contributor.authorImanari, T.
dc.contributor.authorCapila, I.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationEffect of Fully Sulfated Glycosaminoglycans on Pulmonary ArterySmooth Muscle Cell Proliferation, H. G. Garg, P.A.M. Joseph, T. Thompson,C.A. Hales, T. Toida, T. Imanari, I. Capila, R.J. Linhardt, Archivesin Biochemistry and Biophysics, 371, 228-233, 1999.
dc.descriptionArchivesin Biochemistry and Biophysics, 371, 228-233
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractFully sulfated heparin and other glycosaminoglycans, namely heparan, chondroitin, and dermatan sulfates, and hyaluronan have been prepared by using sulfur trioxide under mild chemical conditions. All these derivatives were assayed for antiproliferative activity on cultured bovine pulmonary artery smooth muscle cells (BPASMCs). No appreciable difference was found between heparin and fully sulfated heparin. Chondroitin and dermatan sulfates actually stimulated BPASMCs growth but full sulfonation made them strongly antiproliferative. Native hyaluronan was not antiproliferative but became strongly so after sulfonation. Neither acharan sulfate nor N-sulfoacharan sulfate had any antiproliferative activity. This suggests that O-sulfonation of the polysaccharide is critical for antiproliferative activity, whereas N-sulfonation of glucosamine residues is not.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleEffect of Fully Sulfated Glycosaminoglycans on Pulmonary ArterySmooth Muscle Cell Proliferation
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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