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dc.contributor.authorBazin, H.G.
dc.contributor.authorDu, Y.
dc.contributor.authorPolat, T.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationSynthesis of a Versatile Neuraminic Acid C-Disaccharideas Precursor for the Synthesis of C-Glycoside Analogs of GangliosidesH.G. Bazin, Y. Du, T. Polat, R.J. Linhardt, Journal of Organic Chemistry,64,7254-7259, 1999.
dc.descriptionJournal of Organic Chemistry, 64, 7254-7259
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractGangliosides are cell-surface sialic acid containing glycolipids. They are found in high concentration on the surface of central nervous system cells. Gangliosides are believed to play a role in important biological events such as cell growth regulation, cell−cell adhesion, and malignancy. 1-3 GM4 (1, Scheme 1) is structurally the simplest ganglioside and has been isolated as a minor component from brain, rat kidney, mouse erythrocytes, and chicken egg yolk. 4-6 GM4 is an important cell adhesion molecule in cell growth and tissue regeneration and promotes neuron adhesion through its interaction with myelin-associated glycoprotein. 7 GM3 (2, Scheme 1) was first isolated from equine erythrocytes 8 and is known to modulate the epidermal growth factor (EGF) and the platelet-derived growth factor (PDGF) receptors. 9,10 Tumors, such as those involved in brain cancer, overexpress EGF receptor. GM4 and GM3 are also found in high concentration in tumor cells. 11
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleSynthesis of a Versatile Neuraminic Acid C-Disaccharideas Precursor for the Synthesis of C-Glycoside Analogs of Gangliosides
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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