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    A Novel Fabrication of Poly (e-caprolactone)Microspheres from Blends of Poly (e-caprolactone)and Poly (ethylene glycol) s

    Author
    Lin, W.J.; Flanagan, D.R.; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Other Contributors
    Date Issued
    1999
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    A Novel Fabrication of Poly (e-caprolactone)Microspheres from Blends of Poly (e-caprolactone)and Poly (ethylene glycol) s, W.J. Lin, D.R. Flanagan, R.J. Linhardt,Polymer40,1731-1735, 1999.
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    URI
    https://doi.org/10.1016/S0032-3861(98)00378-4; https://hdl.handle.net/20.500.13015/5885
    Abstract
    A novel method for the preparation of solvent-free poly(ε-caprolactone) (PCL) microspheres from PCL/poly(ethylene glycol) (PEG) blends was developed and demonstrated. The particle size of the PCL spheres are in the range of 1 to 20 μm (mostly in the range 5–10 μm). The influences of the molecular weight of PCL, the molecular weight of PEG, the type of emulsifier, the concentration of plasticizer, the homogenization time and temperature on the characteristics of the PCL microparticles were also investigated. No changes in PCL molecular weight distribution and peak shape were observed, which indicates that the PCL matrix is stable during the fabrication process. However, the microspheres made from low-molecular-weight PCL coalesced into a continuous mass on drying and lost their properties as individual spheres. The surface of the PCL microspheres prepared from PEG 300 as the external phase at 70°C is much smoother than that of the other formulations. The major advantage of this polymer-blend melt technique compared with traditional methods for microsphere preparation is the elimination of methylene chloride or other organic solvents for polymer solubilization. Therefore, the toxicity associated with organic solvent residues resulting from conventional solvent preparation of microspheres is not present with this polymer-blend melt technique.;
    Description
    Polymer, 40,1731-1735; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/S0032-3861(98)00378-4;
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