Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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The Stereospecific Synthesis of KDN a-C-glycosides by Samarium-Mediated Reductive Desulfonylation ofGlycosyl Phenylsulfone, Y. Du, T. Polat, R.J. Linhardt, TetrahedronLetters, 39, 5007-5010, 1998.
KDN, 3-deoxy-D-glycero-D-galacto-2-nonulopyranosylonic acid, is a novel type of sialic acid in which the acetamido group at C-S of N-acetylneuraminic acid is replaced by a hydroxyl group. This ulosonic acid was first isolated from rainbow trout eggs.’ In the last 10 years, a number of KDN-glycoconjugates, exhibiting structural determinants related to human tumor-associated antigens, have been reported in mammals2 In addition, oligo/poly-KDN and KDN-glycoprotein play an important role in the binding of calcium ions.’ KDN-containing gangliosides, KDN-GM3 and KDN-GM4, have been synthesized by Hasegawa’s group and show potent inhibitor activity of cellular immune respones.;
Tetrahedron Letters, 39, 5007-5010; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;