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dc.contributor.authorDu, Y.
dc.contributor.authorPolat, T.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationThe Stereospecific Synthesis of KDN a-C-glycosides by Samarium-Mediated Reductive Desulfonylation ofGlycosyl Phenylsulfone, Y. Du, T. Polat, R.J. Linhardt, TetrahedronLetters, 39, 5007-5010, 1998.
dc.descriptionTetrahedron Letters, 39, 5007-5010
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractKDN, 3-deoxy-D-glycero-D-galacto-2-nonulopyranosylonic acid, is a novel type of sialic acid in which the acetamido group at C-S of N-acetylneuraminic acid is replaced by a hydroxyl group. This ulosonic acid was first isolated from rainbow trout eggs.’ In the last 10 years, a number of KDN-glycoconjugates, exhibiting structural determinants related to human tumor-associated antigens, have been reported in mammals2 In addition, oligo/poly-KDN and KDN-glycoprotein play an important role in the binding of calcium ions.’ KDN-containing gangliosides, KDN-GM3 and KDN-GM4, have been synthesized by Hasegawa’s group and show potent inhibitor activity of cellular immune respones.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleThe Stereospecific Synthesis of KDN a-C-glycosides by Samarium-Mediated Reductive Desulfonylation ofGlycosyl Phenylsulfone
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dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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