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dc.contributor.authorDu, Y.
dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorVlahov, I.R.
dc.date1998
dc.date.accessioned2022-06-27T16:21:52Z
dc.date.available2022-06-27T16:21:52Z
dc.date.issued1998
dc.identifier.citationTetrahedron Report Number 462 - Recent Advances in StereoselectiveC-Glycoside Synthesis, Y. Du, R.J. Linhardt, I.R. Vlahov, Tetrahedron,54,9913-9961, 1998.
dc.identifier.urihttps://doi.org/10.1016/S0040-4020(98)00405-0
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5897
dc.descriptionTetrahedron, 54, 9913-9961
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractCarbohydrate analogs in which a carbon atom substitutes for the glycosidic oxygen are called Cglycosides. During the last two decades, the synthesis of C-glycosides has become an area of intense study among carbohydrate chemists and biochemists because: 1) The discovery of naturally occurring C-nucleosides with important pharmacological properties I gave impetus to synthetic efforts for preparing active carbohydrate analogs; 2) The requirement of C-glycoside chiral building blocks in the synthesis of biologically important macromolecules, such as palytoxin, 2 spongistatin 3,4 and halichondrin B, 5 has stimulated the development of the new synthetic methodologies; 3) C-glycosides are potential inhibitors of carbohydrate processing enzymes and are stable analogs of glycans involved in important intra- and inter-cellular processes. 6-9 C-glycoside synthesis has been reviewed by Postema, 1° Levy, II Sinay, 12 Beau 13 and Nicotra. 6 The aim of the present survey is to provide a summary of the recent applications, published since 1994, of stereoselective methods in the synthesis of C-glycosides. A generalized overview of the most common synthons and intermediates in the C-glycosylation is shown on Scheme 1. The numbers in italics indicate specific sections in this article that describe each synthetic method presented.
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dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleTetrahedron Report Number 462 - Recent Advances in StereoselectiveC-Glycoside Synthesis
dc.typeArticle
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dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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