Interaction of Fibroblast Growth Factor-1 and Related Peptideswith Heparan Sulfate and Its Oligosaccharides
Authors
Fromm, J.R.
Hileman, R.E.
Weiler, J.M.
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1997
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Interaction of Fibroblast Growth Factor-1 and Related Peptideswith Heparan Sulfate and Its Oligosaccharides, J. R. Fromm, R. E. Hileman,J. M. Weiler, R.J. Linhardt, Archives in Biochemistry and Biophysics,346,252-262, 1997.
Abstract
Fibroblast growth factors (FGFs) are a family of an-with the highest affinity to heparan sulfate. These datagiogenic and mitogenic proteins that promote cell divi-suggest the triangular topology of the GAG bindingsion. The binding of FGFs to the heparan sulfate ofsite in FGF is critical for its interaction with heparancell-surface-bound proteoglycans appears to be criti-sulfate. Analysis of known GAG binding sites in 25 pro-cal for their activity. The interaction of fibroblastteins using the Chou – Fasman algorithm show thatgrowth factor-1 (FGF-1 or aFGF) using heparin lyase-these sites commonly contain turns.q1997 Academic Pressderived oligosaccharides from heparan sulfate was in-vestigated.
Description
Archives in Biochemistry and Biophysics, 346, 252-262
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/
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