Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Diastereocontrolled Synthesis of Carbon Glycosides of N-AcetylneuraminicAcid via Glycosyl Samarium(III) Intermediates, I. R. Vlahov, P. I. Vlahov,R.J. Linhardt, Journal of the American Chemical Society, 119,1480-1481, 1997.
α-O-Glycosides of N-acetylneuraminic acid (Neu5Ac, 1, Scheme 1) are often found terminating the oligosaccharide component of cell-surface glycoproteins and glycolipids. Neu5Ac is involved in a number of important biological events: intercellular interactions such as adhesion, aggregation, and agglutination; masking of antigenic oligosaccharides and suppressing undesired immune reactions (antirecognition phenomena); influencing the cell membrane permeability for ions, amino acids, and proteins; and protection of glycoproteins against proteolysis. 1 Terminal Neu5Ac is an attachment site of pathogens to the cells, and often catabolic and inflammatory processes are initiated on the removal of this carbohydrate group. 2 In general the “right” life time of a cell is a reflection of a delicate balance between the introduction and removal of terminal Neu5Ac or other sialic acids.;
Journal of the American Chemical Society, 119, 1480-1481; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;