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dc.contributor.authorVlahov, I.R.
dc.contributor.authorVlahov, P.I.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationDiastereocontrolled Synthesis of Carbon Glycosides of N-AcetylneuraminicAcid via Glycosyl Samarium(III) Intermediates, I. R. Vlahov, P. I. Vlahov,R.J. Linhardt, Journal of the American Chemical Society, 119,1480-1481, 1997.
dc.descriptionJournal of the American Chemical Society, 119, 1480-1481
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractα-O-Glycosides of N-acetylneuraminic acid (Neu5Ac, 1, Scheme 1) are often found terminating the oligosaccharide component of cell-surface glycoproteins and glycolipids. Neu5Ac is involved in a number of important biological events:  intercellular interactions such as adhesion, aggregation, and agglutination; masking of antigenic oligosaccharides and suppressing undesired immune reactions (antirecognition phenomena); influencing the cell membrane permeability for ions, amino acids, and proteins; and protection of glycoproteins against proteolysis. 1 Terminal Neu5Ac is an attachment site of pathogens to the cells, and often catabolic and inflammatory processes are initiated on the removal of this carbohydrate group. 2 In general the “right” life time of a cell is a reflection of a delicate balance between the introduction and removal of terminal Neu5Ac or other sialic acids.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleDiastereocontrolled Synthesis of Carbon Glycosides of N-Acetylneuraminic Acid via Glycosyl Samarium(III) Intermediates
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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