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dc.contributor.authorLinhardt, Robert J.
dc.contributor.authorToida, T.
dc.contributor.authorSmith, A.E.
dc.contributor.authorHileman, R.E.
dc.date1997
dc.date.accessioned2022-06-27T17:13:19Z
dc.date.available2022-06-27T17:13:19Z
dc.date.issued1997
dc.identifier.citationAnalysis of the Structure of Heparin and Heparan Sulfate by HighResolution Separation of Oligosaccharides, R.J. Linhardt, T. Toida, A.E. Smith, R. E. Hileman, in A Laboratory Guide to Glycoconjugate Analysis,J. T. Gallagher, P. Jackson, eds., Birkhauser Verlag AG, Basel, 1997, Chapter10,pp 183-197.
dc.identifier.urihttps://doi.org/10.1007/978-3-0348-7388-8_10
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5931
dc.descriptionin A Laboratory Guide to Glycoconjugate Analysis, J. T. Gallagher, P. Jackson, eds., Birkhauser Verlag AG, Basel, 1997, Chapter 10, pp 183-197
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparin and heparan sulfate are mixtures of highly sulfated linear polysaccharides having a molecular weight (MW) ranging from 5000 to 40,000 with an MW avg of 10,000 to 25,000 (1). They are members of a family of molecules called glycosaminoglycans (GAGs). Both heparin and heparan sulfate are biosynthesized as a repeating →4)α-D-GlcNpAc(1→4)-β-D-GlcAp(1→ disaccharide sequence that undergoes partial N-deacetylation followed by N-sulfation of the newly exposed amino groups, partial C-5 epimerization of D-GlcAp to L-IdoAp and O-sulfation. A single disaccharide sequence, [→4)α-D-GlcNpS6S-(1→4)-a-L-IdoAp2S (1→], accounts for 80 to 90% of the heparin polymer. Minor sequences contain (β-D-GlcAp residues, reduced sulfation as well as N-acetylation. Heparan sulfate is structurally similar to heparin but has substantially lower sulfation. Heparan sulfate consists primarily of unsulfated disaccharide [→4)α-D-GlcNpS-(1→4)-β-D-GlcAp(1 →] and monosulfated disaccharides [→4)α-D-GlcNpS-(1→4)-β-D-GlcAp(1→] and [→4)α-D-GlcNpAc6S(1→4)-β-D-GlcAp(1 →].
dc.description.urihttps://login.libproxy.rpi.edu/login?url=https://doi.org/10.1007/978-3-0348-7388-8_10
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.urihttps://harc.rpi.edu/
dc.subjectBiology
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleAnalysis of the Structure of Heparin and Heparan Sulfate by HighResolution Separation of Oligosaccharides
dc.typeBook chapter
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dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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