Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Preparation and Biological Activity of N-Sulfated Chondroitin and Dermatan Sulfate Derivatives, V. D. Nadkarni, T. Toida, C.L. VanGorp, R.L. Schubert, J.M. Weiler, K.P. Hansen, E. E. O. Caldwell, R.J. Linhardt, Carbohydrate Research, 290, 87-96, 1996.
Chondroitin and dermatan sulfates are families of structurally complex, sulfated, linear polysaccharides called glycosaminoglycans (GAGs) with alternating uronic acid and N-acetylated D-galactosamine residues [ 1] (Scheme 1). Chondroitin sulfate A (1A) consists of unsulfated D-glucuronic acid 1--* 3 linked to N-acetylated, 4-sulfated D-galactosamine, which in turn is attached to the next D-glucuronic acid residue by a 1 ~ 4 linkage. Chondroitin sulfate C (1B) has a 6-sulfate group on the N-acetylated D-galactosamine in place of the 4-sulfate found in chondroitin sulfate A. Dermatan sulfate, also called chondroitin sulfate B (2), is similar to chondroitin sulfate A but instead of D-glucuronic acid it consists mainly of L-iduronic acid. Both dermatan and chondroitin sulfates contain, on the average, one sulfate group per disaccharide unit.;
Carbohydrate Research, 290, 87-96; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;