Author
Desai, Umesh R.; Vlahov, Ioncho R.; Pervin, Azra; Linhardt, Robert J.
Other Contributors
Date Issued
1995-10-02
Subject
Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
Degree
Terms of Use
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Full Citation
Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy, U.R. Desai, I. R. Vlahov, A. Pervin, R. J. Linhardt, Carbohydrate Research, 275, 391-401, 1995.
Abstract
The aluminum salt of sucrose octasulfate (SOS) is a drug called Sucralfate (Carafate), which is widely used for the treatment of duodenal ulcers. Folkman et al. [1] have recently suggested that Sucralfate binds to fibroblast growth factor (FGF), protecting it from denaturation in the strongly acidic conditions present in the stomach. This hypothesis has generated considerable interest in sucrose octasulfate and its interaction with FGF. The sodium and potassium salts of SOS also bind FGF [2], but these differ from Sucralfate in being water soluble and are more easily studied.;
Description
Carbohydrate Research, 275, 391-401; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
Relationships
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Carbohydrate Research; https://harc.rpi.edu/;
Access
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