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    Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy

    Author
    Desai, Umesh R.; Vlahov, Ioncho R.; Pervin, Azra; Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
    Thumbnail
    Other Contributors
    Date Issued
    1995-10-02
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Conformational Analysis of Sucrose Octasulfate by High Resolution Nuclear Magnetic Resonance Spectroscopy, U.R. Desai, I. R. Vlahov, A. Pervin, R. J. Linhardt, Carbohydrate Research, 275, 391-401, 1995.
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    URI
    https://doi.org/10.1016/0008-6215(95)00159-Q; https://hdl.handle.net/20.500.13015/5946
    Abstract
    The aluminum salt of sucrose octasulfate (SOS) is a drug called Sucralfate (Carafate), which is widely used for the treatment of duodenal ulcers. Folkman et al. [1] have recently suggested that Sucralfate binds to fibroblast growth factor (FGF), protecting it from denaturation in the strongly acidic conditions present in the stomach. This hypothesis has generated considerable interest in sucrose octasulfate and its interaction with FGF. The sodium and potassium salts of SOS also bind FGF [2], but these differ from Sucralfate in being water soluble and are more easily studied.;
    Description
    Carbohydrate Research, 275, 391-401; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Carbohydrate Research; https://harc.rpi.edu/;
    Access
    https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1016/0008-6215(95)00159-Q;
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