Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide), E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Macromolecules, 27, 743-748, 1994.
A detailed examination of the role of water in the hydrolysis of poly (DL-lactide/glycolide) esters is reported. The hydrolysisrate of polyester pellets was independent of moderate changes in ionic strength, pH, and buffer concentration. Total water up take by the polymer depended on ionic strength but no tpH.The hydrolysis rates were independent of thetotalwatercontentofthepolymer.Solid-state2H-NMRqualitativelydemonstratedthepresenceoftwotypesofwater(2 20)environmentswithinthepolymer,bulkwaterwithfreerotationandboundwaterwithhinderedrotation.Differentialscanningcalorimetryalsoshowedthepresenceofnonfreezingwater,confirmingdifferentwaterenvironmentswithinthepolymers.Quantitativesolid-state2H-NMRshowedthatthepolymercontainedaconstantamountofwater(2H20)withhinderedrotation.Themolarquantityofestergroupsinthepolymeris25-foldhigherthanthemolarquantityofwaterwithhinderedrotation,suggestingthatwater’simmobilityandreactivityresultfromitsselectivehydrogenbondingtotheoxygenofestercarbonylgroups.Theincreasedhydrolysisrate,observedforpolyesterswithhigherglycolidecontent,correlateswithanobservedincreaseinbound,reactivewater.;
Macromolecules, 27, 743-748,; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;