| dc.contributor.author | Schmitt, E.A. | |
| dc.contributor.author | Flanagan, D.R. | |
| dc.contributor.author | Linhardt, Robert J. | |
| dc.date | 1994 | |
| dc.date.accessioned | 2022-06-27T17:14:13Z | |
| dc.date.available | 2022-06-27T17:14:13Z | |
| dc.date.issued | 1994 | |
| dc.identifier.citation | Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide), E.A. Schmitt, D.R. Flanagan, R.J. Linhardt, Macromolecules, 27, 743-748, 1994. | |
| dc.identifier.uri | https://doi.org/10.1021/ma00081a019 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.13015/5965 | |
| dc.description | Macromolecules, 27, 743-748, | |
| dc.description | Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform. | |
| dc.description.abstract | A detailed examination of the role of water in the hydrolysis of poly (DL-lactide/glycolide) esters is reported. The hydrolysisrate of polyester pellets was independent of moderate changes in ionic strength, pH, and buffer concentration. Total water up take by the polymer depended on ionic strength but no tpH.The hydrolysis rates were independent of thetotalwatercontentofthepolymer.Solid-state2H-NMRqualitativelydemonstratedthepresenceoftwotypesofwater(2 20)environmentswithinthepolymer,bulkwaterwithfreerotationandboundwaterwithhinderedrotation.Differentialscanningcalorimetryalsoshowedthepresenceofnonfreezingwater,confirmingdifferentwaterenvironmentswithinthepolymers.Quantitativesolid-state2H-NMRshowedthatthepolymercontainedaconstantamountofwater(2H20)withhinderedrotation.Themolarquantityofestergroupsinthepolymeris25-foldhigherthanthemolarquantityofwaterwithhinderedrotation,suggestingthatwater’simmobilityandreactivityresultfromitsselectivehydrogenbondingtotheoxygenofestercarbonylgroups.Theincreasedhydrolysisrate,observedforpolyesterswithhigherglycolidecontent,correlateswithanobservedincreaseinbound,reactivewater. | |
| dc.description.uri | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/ma00081a019 | |
| dc.language | en_US | |
| dc.language.iso | ENG | |
| dc.relation.ispartof | The Linhardt Research Labs Online Collection | |
| dc.relation.ispartof | Rensselaer Polytechnic Institute, Troy, NY | |
| dc.relation.uri | https://harc.rpi.edu/ | |
| dc.subject | Biology | |
| dc.subject | Chemistry and chemical biology | |
| dc.subject | Chemical and biological engineering | |
| dc.subject | Biomedical engineering | |
| dc.title | Importance of Distinct Water Environments in the Hydrolysis of Poly(D,L-lactide-co-glycolide | |
| dc.type | Article | |
| dcterms.accessRights | https://login.libproxy.rpi.edu/login?url=https://doi.org/10.1021/ma00081a019 | |
| dc.rights.holder | In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/ | |
| dc.creator.identifier | https://orcid.org/0000-0003-2219-5833 | |
| dc.relation.department | The Linhardt Research Labs. | |
| dc.relation.department | The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) | |
