Comparison of the Activity of Two Chondroitin AC Lyases on Dermatan Sulfate
Authors
Gu, Kenan
Liu, Jian
Pervin, Azra
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1993-06-21
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
Comparison of the Activity of Two Chondroitin AC Lyases on Dermatan Sulfate, K. Gu, J. Liu, A. Pervin, R.J. Linhardt, Carbohydrate Research, 244, 369-377 (1993).
Abstract
Chondroitin sulfates are widely distributed in human and animal tissues and are the main constituents of cartilage’. The two major isomeric chondroitin sulfates, A (ChS-A) and C (ChS-C) are isolated as glycosaminoglycan from the proteoglycans present in tissues’. Structural investigations have shown that ChS-A and ChS-C both are co-polymers of D-glucuronic acid and sulfated 2-acetamido-2-deoxy-pgalactose. ChS-A primarily contains 4-sulfated 2-acetamido-2-deoxy-D-galactose residues, while ChS-C primarily contains 6-sulfated 2-acetamido-2-deoxy-o-galactose residues. Dermatan sulfate (DS) is a related glycosaminoglycan, often called chondroitin sulfate B (ChS-B), composed of 4-sulfated 2-acetamido-2-deoxy-ogalactose residues. DS differs from ChS-A and ChS-C since its primary uranic acid residue is L-iduronic acid instead of p-glucuronic acid. Despite these structural differences ChS-A, ChS-C, and DS also contain the minor uranic acid C-S epimer (L-iduronic acid in ChS-A and ChS-C and p-glucuronic acid in DS) in their structures.
Description
Carbohydrate Research, 244, 369-377
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Research
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
Carbohydrate Research
https://harc.rpi.edu/
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