Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Nature of the Interaction of Heparin with Acidic Fibroblast Growth Factor, H. Mach, D.B. Volkin, C.J. Burke, C.R. Middaugh, R.J. Linhardt, J. Fromm, D. Loganathan, L. Mattsson, Biochemistry, 32, 5480-5489 (1993).
In the course of development of potentially more bioactive forms of heparin for use as an anticoagulant, we had occasion to prepare a modified heparin first reported by Jaseja et al.‘. Treatment of unfractionated bovine lung heparin with an alkaline solution at high temperature (105-110°C) for 24 h, according to method developed by Rej and Perlin3, results in a modified heparin. To structurally characterize the sample of modified heparin, it was depolymerized with heparinase (heparin lyase I, EC 18.104.22.168). This resulted in the isolation of the hitherto unreported tetrasaccharide and hexasaccharide. This note describes the isolation and structure elucidation of two novel oligosaccharides. The solution conformation of these oligosaccharides may aid in developing a better understanding of the conformational preferences of the uranic acid residues.;
Carbohydrate Research, 241, 249-259; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; Carbohydrate Research; https://harc.rpi.edu/;