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dc.contributor.authorDesai, Umesh R.
dc.contributor.authorWang, Hui Ming
dc.contributor.authorKelly, Therese R.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationNature of the Interaction of Heparin with Acidic Fibroblast Growth Factor, H. Mach, D.B. Volkin, C.J. Burke, C.R. Middaugh, R.J. Linhardt, J. Fromm, D. Loganathan, L. Mattsson, Biochemistry, 32, 5480-5489 (1993).
dc.descriptionCarbohydrate Research, 241, 249-259
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractIn the course of development of potentially more bioactive forms of heparin for use as an anticoagulant, we had occasion to prepare a modified heparin first reported by Jaseja et al.‘. Treatment of unfractionated bovine lung heparin with an alkaline solution at high temperature (105-110°C) for 24 h, according to method developed by Rej and Perlin3, results in a modified heparin. To structurally characterize the sample of modified heparin, it was depolymerized with heparinase (heparin lyase I, EC This resulted in the isolation of the hitherto unreported tetrasaccharide and hexasaccharide. This note describes the isolation and structure elucidation of two novel oligosaccharides. The solution conformation of these oligosaccharides may aid in developing a better understanding of the conformational preferences of the uranic acid residues.
dc.description.sponsorshipNational Institute of General Medical Sciences
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofCarbohydrate Research
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleStructure Elucidation of a Novel Acidic Tetrasaccharide and Hexasaccharide Derived From a Chemically Modified Heparin
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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