Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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New Methodologies in Heparin Structure Analysis and the Generation of Low Molecular Weight Heparins, R.J. Linhardt, H.M. Wang, S.A. Ampofo, in Heparin and Related Polysaccharides, Plenum Press, New York, D. Lane and U. Lindahl (Eds.), pp. 37-47, 1992.
This chapter examines the methods used to prepare heparin, low molecular weight (LMW) heparins, and immobilized heparins. These heparins and heparin derivatives arc polydispcrse heterogeneous mixtures that require structural characterization. Analyses rely on integrated enzymatic, chemical, chromatographic, electrophoretic and spectroscopic techniques. Tile goal is to establish the physical-chemical properties of a heparin preparation as well as the exact composition, distribution and sequence of the polysaccharide chains that are present. Ultrasensitive analytical techniques are also described for the analysis of heparin in tissues and biological fluids.;
in Heparin and Related Polysaccharides, Plenum Press, New York, D. Lane and U. Lindahl (Eds.), pp. 37-47; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;