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dc.contributor.authorWang, H.T.
dc.contributor.authorSchmitt, E.
dc.contributor.authorFlanagan, D.R.
dc.contributor.authorLinhardt, Robert J.
dc.identifier.citationInfluence of Formulation Methods on the In Vitro Controlled Release of Protein from Poly(Ester) Microspheres, H.T. Wang, E. Schmitt, D.R. Flanagan, R.J. Linhardt, Journal of Controlled Release, 17, 23-32 (1991).
dc.descriptionJournal of Controlled Release, 17, 23-32
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractPoly (dl-lactide/glycolide, 50:50) microspheres containing bovine serum albumin (BSA) were pre-pared with and without Carbopol® 951 (a potential adjuvant agent) by o/o, o/w and (w/o) /w emul-sion methods. The protein loading of the microspheres reached 50%–70% of the theoretical amount of protein put into the formulation medium. The microsphere particle size was approximately 500 μm, 25–100μm, 10–20/nn using o/o, o/w, or (w/o)/w emulsion techniques, respectively. The release of BSA was dependent on the preparation method. The greatest burst of release was found for vacuum-dried microspheres formulated using the (w/o)/w method. This burst effect could be eliminated by lyophilizing the microspheres following their preparation. BSA was released at a higher initial rate from microspheres prepared by the o/w emulsion method that contained Carbopol® 951 than from micro-spheres not containing Carbopol® 951. Release studies also suggested that the release of BSA could be sustained for 54, 36, or 34 days for microspheres prepared by o/o, o/w, or (w/o)/w methods, respectively.
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.titleInfluence of Formulation Methods on the In Vitro Controlled Release of Protein from Poly(Ester) Microspheres
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s).
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)

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