Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
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Modification and Potential Uses of Heparin and Other Acidic Polysaccharides, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491 (1990).
Heparin lo a polydisperse, highly sulfated, linear polysaccharide of repeating uronic acid and glucosamine residues (Figure 1). Although heperin has been used clinically as an anticoagulant for the past 5O years, its precise structure remains unknown . Heparin is biosynthesized as a proteoglycan (PG, Mr~1 million) consisting of a central core protein from which 10-11 long, linear polysaccharide chains extend . The drug heparin is recovered from porcine 1ntestinal musosa or bovine lung as a glycosaminoglycan (GAG), a linear polysaccharide chain without anyassociated protein. GAG heparin has a Mr ranging from 5,000-40,000 (degree of polymerization (dp) 10-80) with an Mr(avg) of 13,000. Even the heporln chain corresponding to the most prevalent dp represents a mere 5 mo1% of a typical GAG heparin preparation . GAG heparln has a second level of structuralcomplexity associated with its primary structure or sequence .;
Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;