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    Modification and Potential Uses of Heparin and Other Acidic Polysaccharides

    Author
    Linhardt, Robert J.
    ORCID
    https://orcid.org/0000-0003-2219-5833
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    Date Issued
    1990
    Subject
    Biology; Chemistry and chemical biology; Chemical and biological engineering; Biomedical engineering
    Degree
    Terms of Use
    In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/;
    Full Citation
    Modification and Potential Uses of Heparin and Other Acidic Polysaccharides, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491 (1990).
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    URI
    http://dx.doi.org/10.1002/chin.199114324; https://hdl.handle.net/20.500.13015/6006
    Abstract
    Heparin lo a polydisperse, highly sulfated, linear polysaccharide of repeating uronic acid and glucosamine residues (Figure 1). Although heperin has been used clinically as an anticoagulant for the past 5O years, its precise structure remains unknown [1]. Heparin is biosynthesized as a proteoglycan (PG, Mr~1 million) consisting of a central core protein from which 10-11 long, linear polysaccharide chains extend [2]. The drug heparin is recovered from porcine 1ntestinal musosa or bovine lung as a glycosaminoglycan (GAG), a linear polysaccharide chain without anyassociated protein. GAG heparin has a Mr ranging from 5,000-40,000 (degree of polymerization (dp) 10-80) with an Mr(avg) of 13,000. Even the heporln chain corresponding to the most prevalent dp represents a mere 5 mo1% of a typical GAG heparin preparation [3]. GAG heparln has a second level of structuralcomplexity associated with its primary structure or sequence [4].;
    Description
    Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491; Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
    Department
    The Linhardt Research Labs.; The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS);
    Relationships
    The Linhardt Research Labs Online Collection; Rensselaer Polytechnic Institute, Troy, NY; https://harc.rpi.edu/;
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