Modification and Potential Uses of Heparin and Other Acidic Polysaccharides
Authors
Linhardt, Robert J.
ORCID
https://orcid.org/0000-0003-2219-5833
No Thumbnail Available
Other Contributors
Issue Date
1990
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
In Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
Full Citation
Modification and Potential Uses of Heparin and Other Acidic Polysaccharides, R.J. Linhardt, Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491 (1990).
Abstract
Heparin lo a polydisperse, highly sulfated, linear polysaccharide of repeating uronic acid and glucosamine residues (Figure 1). Although heperin has been used clinically as an anticoagulant for the past 5O years, its precise structure remains unknown [1]. Heparin is biosynthesized as a proteoglycan (PG, Mr~1 million) consisting of a central core protein from which 10-11 long, linear polysaccharide chains extend [2]. The drug heparin is recovered from porcine 1ntestinal musosa or bovine lung as a glycosaminoglycan (GAG), a linear polysaccharide chain without anyassociated protein. GAG heparin has a Mr ranging from 5,000-40,000 (degree of polymerization (dp) 10-80) with an Mr(avg) of 13,000. Even the heporln chain corresponding to the most prevalent dp represents a mere 5 mo1% of a typical GAG heparin preparation [3]. GAG heparln has a second level of structuralcomplexity associated with its primary structure or sequence [4].
Description
Proceedings of the ACS Division of Polymeric Materials: Science and Engineering, 62, 488-491
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/
Rensselaer Polytechnic Institute, Troy, NY
https://harc.rpi.edu/