An Enzymatic System for Removing Heparin in Extracorporeal Therapy

Authors
Langer, Robert
Linhardt, Robert J.
Hoffberg, Steven
Larsen, Annette K.
Cooney, Charles L.
Tapper, David
Klein, Michael
ORCID
https://orcid.org/0000-0003-2219-5833
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Other Contributors
Issue Date
1982-01-01
Keywords
Biology , Chemistry and chemical biology , Chemical and biological engineering , Biomedical engineering
Degree
Terms of Use
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Full Citation
An Enzymatic System for Removing Heparin in Extracorporeal Therapy, R. Langer, R.J. Linhardt, C.L. Cooney, M. Klein, D. Tapper, S.M. Hoffberg, A. Larsen, Science, 217, 261-263 (1982).
Abstract
The need to fully heparinize patients undergoing extracorporeal therapy often leads to hemorrhagic complications. To enable heparinization of only the extracorporeal circuit, a blood filter containing immobilized heparinase was developed. This filter degraded 99 percent of heparin's anticoagulant activity within minutes in both canine and human blood.
Description
Science, 217, 261-263
Note : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
Department
The Linhardt Research Labs.
The Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)
Publisher
Relationships
The Linhardt Research Labs Online Collection
Rensselaer Polytechnic Institute, Troy, NY
Science
https://harc.rpi.edu/
Access
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