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dc.contributor.authorLiu, J.
dc.contributor.authorWang, Z.
dc.contributor.authorArnold, K.
dc.contributor.authorXu, Y.
dc.contributor.authorPagadala, V.
dc.contributor.authorSu, G.
dc.contributor.authorMyatt, H.
dc.contributor.authorLinhardt, Robert J.
dc.date2020
dc.date.accessioned2022-06-27T15:40:48Z
dc.date.available2022-06-27T15:40:48Z
dc.date.issued2020
dc.identifier.citationDeveloping a quantitative method to analyze heparan sulfate using isotopically labeled calibrants, Z. Wang, K. Arnold, Y. Xu, V. Pagadala, G. Su, H. Myatt, R.J. Linhardt, J. Liu, Communications Biology, 3, 425, 2020.
dc.identifier.urihttps://hdl.handle.net/20.500.13015/5489
dc.identifier.urihttps://doi.org/10.1038/s42003-020-01150-6
dc.descriptionCommunications Biology, 3, 425
dc.descriptionNote : if this item contains full text it may be a preprint, author manuscript, or a Gold OA copy that permits redistribution with a license such as CC BY. The final version is available through the publisher’s platform.
dc.description.abstractHeparan sulfate is a sulfated polysaccharide that displays essential physiological functions. Here, we report a LC-MS/MS-based method for quantitatively determining the individual disaccharide composition and total amount of heparan sulfate. Using eight 13C-labeled disaccharide calibrants and one 13C-labeled polysaccharide calibrant, we complete the analysis in one-pot process. The method is both sensitive and has the throughput to analyze heparan sulfate from mouse tissues and plasma.
dc.languageen_US
dc.language.isoENG
dc.relation.ispartofRensselaer Polytechnic Institute, Troy, NY
dc.relation.ispartofThe Linhardt Research Labs Online Collection
dc.relation.urihttps://harc.rpi.edu/
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subjectChemistry and chemical biology
dc.subjectChemical and biological engineering
dc.subjectBiomedical engineering
dc.subjectBiology
dc.titleQuantitative analysis of heparan sulfate using isotopically labeled calibrants
dc.typeArticle
dcterms.accessRightsA full text version is available in DSpace@RPI
dcterms.isVersionOfhttps://doi.org/10.1038/s42003-020-01150-6
dc.rights.holderIn Copyright : this Item is protected by copyright and/or related rights. You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). https://rightsstatements.org/page/InC/1.0/
dc.creator.identifierhttps://orcid.org/0000-0003-2219-5833
dc.relation.departmentThe Linhardt Research Labs.
dc.relation.departmentThe Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS)


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Attribution 3.0 United States
Except where otherwise noted, this item's license is described as Attribution 3.0 United States